2024
Roberts RJ, Lam CK
Application of Calcium Kinetics Characterization in Cardiac Disease Modeling and Drug Discovery
Biomolecules. 2024, 14(7), 865
Lazzarino M, Zannetti M, Chen SN, Gao S, Pena B, Lam CK, Wu JC, Taylor MRG, Mestroni L, Sbaizero O
Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations
Int. J. Mol. Sci. 2024, 25(5), 2942
Gao S, He L, Lam CK, Taylor MRG, Mestroni L, Lombardi R, Chen SN
Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Cells 2024, 13(3), 278
2023
Tu C, Caudal A, Liu Y, Gorgodze N, Zhang H, Lam CK, Dai Y, Zhang A, Wnorowski A, Wu MA, Yang H, Abilez OJ, Lyu X, Narayan SM, Mestroni L, Taylor MRG, Recchia FA, Wu JC
Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction
Nat Biomed Eng. 2023; Nov 27
Ramachandran A, Livingston CE, Vite A, Corbin EA, Bennet AI, Turner KT, Lee BW, Lam CK, Wu JC, Margulies KB
Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload
J Cardiovasc Trans Res. 2023; Aug;16(4):828-841
2022
Wang YJ, Zhang X, Lam CK, Guo H, Wang C, Zhang S, Wu JC, Snyder M, Li J
Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome
Cell Syst. 2022; 13, 1-16
Zhang M, Lam CK
CaMKII: Therapeutic Target in Vascular Diseases Warranted for Clinical and Translational Discovery?
Clin Transl Disc. 2022; 2:e119
Chen SN*, Lam CK*, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L
Activation of PDGFRA signaling contributes to filamin C–related arrhythmogenic cardiomyopathy
Sci Adv 2022, 8, eabk0052
2021
Roberts RJ, Hallee L, Lam CK
The Potential of Hsp90 in Targeting Pathological Pathways in Cardiac Diseases
J. Pers. Med.2021, 11(12), 1373
Sen S, Hallee L, Lam CK
The Potential of Gamma Secretase as a Therapeutic Target for Cardiac Diseases
J. Pers. Med. 2021, 11(12), 1294
Lam CK, Wu JC
Clinical Trial in a Dish: Using Patient-Derived Induced Pluripotent Stem Cells to Identify Risks of Drug-Induced Cardiotoxicity
Arteriorscler Thomb Vasc Biol. 2021 Mar;41(3):1019-1031
2020
Feyen DA, McKeithan WL, Bruyneel AA, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen R, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RG, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola MM
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Cell Rep. 2020 Jul 21;32(3):107925
Rhee JW, Yi H, Thomas D, Lam CK, Belbachir N, Tian L, Qin X, Malisa J, Lau E, Paik DT, Kim Y, Choi BS, Sayed N, Sallam K, Liao R, Wu JC.
Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Cell Rep. 2020 Jul 14;32(2):107886
2019
Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee J-W, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC.
Activation of PDGF Pathway Links LMNA Mutation to Dilated Cardiomyopathy.
Nature. 2019 Aug;572(7769):335-340.
Lam CK, Tian L, Belbachir N, Shrestha R, Ma N, Kitani T, Rhee JW, Wnorowski A, Wu JC.
Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Circ Res. 2019 Jul 5;125(2):212-222.
Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC.
Modeling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.
Eur Heart J. 2019 Dec 1;40(45):3685-3695.
Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC.
Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer.
Circulation. 2019 May 21; 139(21):2451-2465.
Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC.
A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.
Cell Stem Cell. 2019 May 2;24(5):802-811.
Seeger T, Shrestha R, Lam CK, Chen C, Mckeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC.
A Premature Termination Codon Mutation of MYBP3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.
Circulation. 2019 Feb 5;139(6):799-811.
2018
Ma N, Zhang J, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC.
Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells.
Circulation. 2018 Dec 4;138(23):2666-2681.
Garg P, Oikonomopoulos A, Chen H, Li Y, Lam CK, Sallam K, Perez M, Lux RL, Sanguinetti MC, Wu JC.
Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant.
J Am Coll Cardiol. 2018 Jul 3;72(1):62-75.
Lam CK, Wu JC.
Disease Modelling and Drug Discovery for Hypertrophic Cardiomyopathy Using Pluripotent Stem Cells: How Far Have We Come?
Eur Heart J. 2018 Nov 14;39(43):3893-3895.
Liu GS, Gardner G, Adly G, Jiang M, Cai WF, Lam CK, Alogaili F, Robbins N, Rubinstein J, Kranias EG.
A Novel Human S10F-Hsp20 Mutation Induces Lethal Peripartum Cardiomyopathy.
J Cell Mol Med. 2018 May 15;22(8): 3911–3919.
2017
Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, Kranias EG.
HAX-1 Regulates SERCA2a Oxidation and Degradation.
J Mol Cell Cardiol. 2017 Nov 21;114:220-233
Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Adly G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, Fan GC, Kranias EG.
Regulation of BECN1-Mediated Autophagy by HSPB6: Insights from A Human HSPB6S10F Mutant.
Autophagy. 2017 Nov 20:1-56.
2016
Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Termglinchan V, Lam F, Gu M, Gong T, Zhuge Y, He C, Ebert A, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman M, Bers D, Wu JC.
Patient-specific and Genome-edited Induced Pluripotent Stem Cell-derived Cardiomyocytes Elucidate Single Cell Phenotype of Brugada Syndrome.
J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096
2015
Lam CK, Zhao W, Liu G, Cai W, Gardner G, Adly G, Kranias EG.
HAX-1 Is a New Regulator of Cyclophilin-D Levels and the Mitochondrial Permeability Transition Pore in the Heart.
Proc Natl Acad Sci USA. 2015 Nov 24;112(47): E6466-75.
Pritchard TJ, Haghighi K, Singh VP, Bidwell P, Liu GS, Lam CK, Vafiadaki L, Das P, Florea S, Vanderbilt E, Rubinstein J, Hajjar RJ, Kranias EG.
Human G109E-Inhibitor-1 Impairs Cardiac Function and Promotes Arrhythmias.
J Mol Cell Cardiol. 2015 Dec;89(Pt B):349-59.
Cai W, Liu G, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajiar RJ, Kranias EG.
Micro-RNA765 Targets Protein Phosphatase Inhibitor-1 and Suppresses Contractility.
Eur J Heart Fail. 2015 Aug;17(8):782-93.
Liu G, Morales A, Vafiadaki E, Lam CK, Haghighi K, Adly G, Hershberger RE, Kranias EG.
A Novel Human R25C-Phospholamban Mutation Is Associated with Superinhibition of Calcium Cycling and Ventricular Arrhythmia.
Cardiovasc Res. 2015 Jul 1;107(1):164-74.
2013
Lam CK, Zhao W, Cai W, Vafiadaki E, Florea S, Ren XP, Liu Y, Robbins N, Zhang Z, Zhou X, Jiang M, Rubinstein J, Jones WK, Kranias EG.
Novel Role of HAX-1 in Ischemic Injury Protection: Involvement of Hsp90.
Circ. Res. 2013 Jan 4;112(1):79-89.
2012
Cai W, Pritchard T, Florea S, Lam CK, Han P, Zhou X, Yuan Q, Lehnart SE, Allen PD, Kranias EG.
Ablation of Junctin or Triadin Is Associated with Increased Cardiac Injury Following Ischaemia/reperfusion.
Cardiovasc Res. 2012 May 1;94(2):333-41.
2011
Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh V, Chen S, Zhang H, Zhang R, Chen H, Kranias EG.
Catecholaminergic Induced Arrhythmias in Failing Cardiomyocytes Associated with Human HRCS96A Variant Overexpression.
Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1588-95.
Qian J, Vafiadaki E, Florea SM, Singh VP, Song W, Lam CK, Wang Y, Yuan Q, Pritchard TJ, Haghighi K, Rodriguez P, Wang HS, Sanoudou D, Fan GC, Kranias EG.
Small Heat Shock Protein 20 Interacts with Protein Phosphatase-1 And Enhances Sarcoplasmic Reticulum Calcium Cycling.
Circ Res. 2011 Jun 10;108(12):1429-38.
Wang HS, Arvanitis DA, Dong M, Niklewski PJ, Zhao W, Lam CK, Kranias EG, Sanoudou D.
SERCA2a Superinhibition by Human Phospholamban Triggers Electrical and Structural Remodeling in Mouse Hearts.
Physiol Genomics. 2011 Apr 12;43(7):357-64.
Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD.
Mitigation of Muscular Dystrophy in Mice by SERCA Overexpression in Skeletal Muscle.
J Clin Invest. 2011 Mar;121(3):1044-52.
2009
Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A., Robia SL, Kranias EG.
The Anti-apoptotic Protein HAX-1 Is a Regulator of Cardiac Function.
Proc. Natl Acad Sci USA. 2009 Dec 8;106(49):20776-81.